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- Title
Sleep and circadian rhythms: Key components in the regulation of energy metabolism
- Authors
Laposky, Aaron D.; Bass, Joseph; Kohsaka, Akira; Turek, Fred W.
- Abstract
Abstract: In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesity and diabetes. The first part of this review will focus on studies that support the idea that sleep loss and obesity are “interacting epidemics.” The second part will discuss recent evidence that the circadian clock system plays a fundamental role in energy metabolism at both the behavioral and molecular levels. These lines of research must be seen as in their infancy, but nevertheless, have provided a conceptual and experimental framework that potentially has great importance for understanding metabolic health and disease.
- Subjects
ENERGY metabolism; CIRCADIAN rhythms; METABOLISM; PHYSIOLOGY
- Publication
FEBS Letters, 2008, Vol 582, Issue 1, p142
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.06.079