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- Title
Does F<sub>1</sub>-ATPase have a catalytic site that preferentially binds MgADP?
- Authors
Mao, Hui Z.; Gray, Wesley D.; Weber, Joachim
- Abstract
Abstract: During ATP synthesis, ATP synthase has to bind MgADP in the presence of an excess of MgATP. Thus, for efficient ATP synthesis it would be desirable if incoming substrate could be bound to a catalytic site with a preference for MgADP over MgATP. We tested three hypotheses predicting the existence of such a site. However, our results showed that, at least in absence of an electrochemical proton gradient, none of the three catalytic sites has a higher affinity for MgADP than for MgATP.
- Subjects
ADENOSINE triphosphatase; ENZYMES; PROTONS; CONSTITUTION of matter
- Publication
FEBS Letters, 2006, Vol 580, Issue 17, p4131
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.06.059