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- Title
GLP-1 Analogues as a Complementary Therapy in Patients after Metabolic Surgery: a Systematic Review and Qualitative Synthesis.
- Authors
Schneider, Romano; Kraljević, Marko; Peterli, Ralph; Rohm, Theresa V.; Klasen, Jennifer M.; Cavelti-Weder, Claudia; Delko, Tarik
- Abstract
The evidence is strong that bariatric surgery is superior to medical treatment in terms of weight loss and comorbidities in patients with severe obesity. However, a considerable part of patients presents with unsatisfactory response in the long term. It remains unclear whether postoperative administration of glucagon-like peptide-1 analogues can promote additional benefits. Therefore, a systematic review of the current literature on the management of postoperative GLP-1 analogue usage after metabolic surgery was performed. From 4663 identified articles, 6 met the inclusion criteria, but only one was a randomized controlled trial. The papers reviewed revealed that GLP-1 analogues may have beneficial effects on additional weight loss and T2D remission postoperatively. Thus, the use of GLP-1 analogues in addition to surgery promises good results concerning weight loss and improvements of comorbidities and can be used in patients with unsatisfactory results after bariatric surgery.
- Subjects
META-analysis; BARIATRIC surgery; GASTRIC bypass; RANDOMIZED controlled trials; SURGERY; THERAPEUTICS
- Publication
Obesity Surgery, 2020, Vol 30, Issue 9, p3561
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-020-04750-7