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- Title
SEXUAL DIMORPHISM IN SARS-COV-2 INFECTION.
- Authors
Ulhaq, Z. S.; Soraya, G. V.; Zambrano, L. E. A.; Garcia, C. P.
- Abstract
Previous studies have demonstrated that female patients with coronavirus disease 2019 (COVID-19) demonstrate more favorable prognosis relative to male patients. In this article, we elaborate the possible role of estrogen in the modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection severity. The potential interplay between several factors, including inherently lower estradiol (E2) and slightly higher estrogen receptor β (ERβ) levels in males, with inflammatory mediators are described. Altogether, there seems to be a sexually dimorphic response towards SARS-CoV-2 infection, and a possibility that COVID-19 severity is dependent on both E2 levels and ERα:ERβ expression ratio in lymphoid and lung cells.
- Subjects
COVID-19; SARS-CoV-2; SEXUAL dimorphism; INFLAMMATORY mediators; ESTROGEN receptors
- Publication
Acta Endocrinologica (1841-0987), 2020, Vol 16, Issue 4, p522
- ISSN
1841-0987
- Publication type
Article
- DOI
10.4183/aeb.2020.522