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- Title
EVALUATION OF RENAL FUNCTIONS IN PATIENTS TREATED WITH COLISTIN.
- Authors
Demirtürk, Neşe; Demir, Serap; Aşçı, Zerrin; Doğan, Nurhan
- Abstract
Objective: Colistin belongs to the polymyxin group of antibiotics, of which use was ceased in previous years due to nephrotoxic side effects. However, recent trials suggest that nephrotoxicity is not observed as frequently as previously believed, and patients who develop nephrotoxicity have accompanying risk factors. In this study, we aimed to investigate the frequency of nephrotoxicity and the risk factors that might cause nephrotoxicity in patients treated with colistin. Material and Method: Patients who were hospitalized and treated with colistin for a minimum of one day were included in the study. The frequency of nephrotoxicity was evaluated and the risk factors that might have contributed to nephrotoxicity (older age, heart failure, hypoalbuminemia, hypovolemia, hypotension, mechanical ventilation, and other nephrotoxic drugs) were studied. Results: The study included 67 patients. Nephrotoxicity was found in 65.7% of the patients. When the risk factors were evaluated, older age and hypotension were found to be more frequent (p-0.02 andp=0.01, respectively) inpatients who developed nephrotoxicity than in those who did not. Twenty-one patients who did not develop nephrotoxicity and 42 patients who developed nephrotoxicity were found to use other nephrotoxic drugs in addition to colistin; additional drug usage increased the risk of renal failure two-fold (odds ratio: 2; Cl: 0,263-15,209). Conclusion: Nephrotoxicity is a significant and frequent adverse effect that may occur during colistin use. Patient risk factors may increase the possibility of developing renal failure. Thus, before administration of colistin, patients must be evaluated for other risk factors that may cause nephrotoxicity.
- Subjects
COLISTIN; ANTIBIOTICS; NEPHROTOXICOLOGY; POLYMYXIN; HYPOTENSION
- Publication
Nobel Medicus Journal, 2016, Vol 12, Issue 1, p74
- ISSN
1305-2381
- Publication type
Article