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- Title
In vivo and In vitro Control of Leishmania mexicana due to Garlic-induced NO Production.
- Authors
Gamboa-León, M. R.; Aranda-González, I.; Mut-Martín, M.; García-Miss, M. R.; Dumonteil, E.
- Abstract
Leishmania mexicana is the main causal agent of cutaneous leishmaniasis in the Yucatán peninsula in Mexico. Control of this disease is associated with a Th1-type immune response and garlic extract has been reported as a Th1 immunomodulator in BALB/ c mice infected with Leishmania major. In this study, we investigated the effect of garlic extracts on L. mexicana infection in vivo and in vitro. Garlic extract reduced footpad lesions in L. mexicana-infected BALB/ c mice by inducing IFN-γ production from T cells. In vitro, garlic extract reduced macrophage infection through induction of nitric oxide (NO) production. Garlic extract may thus act on both T cells and macrophages to stimulate IFN-γ production and NO synthesis for parasite killing. A 10- to 14-kDa fraction was identified as responsible for the in vitro effect of the whole extract and may lead to the identification of novel immunomodulating drugs and therapeutic alternatives for the treatment of leishmaniasis.
- Subjects
ALLIUM; GARLIC; LEISHMANIASIS; PROTOZOAN diseases; LYMPHOCYTES; T cells; IMMUNOLOGICAL adjuvants; KILLER cells
- Publication
Scandinavian Journal of Immunology, 2007, Vol 66, Issue 5, p508
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.2007.02000.x