The article discusses a research on the role of the mammalian target of rapamycin (mTOR) in controling feeding. It references a study by D. Cota and colleagues in the previous issue of "Science." It has been discovered that the activity of mTOR signaling complex 1 (TORC1) were especially pronounced in the arcuate nucleus and that fasting inhibited TORC1 signaling specifically in the arcuate nucleus, whereas re-feeding stimulated it.