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- Title
Paratesticular rhabdomyosarcoma: delayed effects of multimodality therapy and implications for current management.
- Authors
Hughes, Lorie L.; Baruzzi, Maria J.; Ribeiro, Raul C.; Ayers, Gregory D.; Rao, Bhaskar; Parham, David M.; Pratt, Charles B.; Kun, Larry E.; Hughes, L L; Baruzzi, M J; Ribeiro, R C; Ayers, G D; Rao, B; Parham, D M; Pratt, C B; Kun, L E
- Abstract
<bold>Background: </bold>The combined modalities of surgery, chemotherapy, and radiation therapy have greatly improved the survival rate in childhood paratesticular rhabdomyosarcoma, but the incidence of complications and late side effects is a cause for concern.<bold>Methods: </bold>We reviewed the records of 18 patients treated for paratesticular rhabdomyosarcoma at St. Jude Children's Research Hospital between 1962 and 1989. Patients with Group I disease were treated with orchiectomy, retroperitoneal lymph node dissection, and multi-agent chemotherapy; more advanced cases also received radiation therapy with concurrent chemotherapy.<bold>Results: </bold>Sequelae included esophageal and common bile duct stricture, inguinal nerve entrapment syndrome, and small bowel obstruction. Short stature was found in all children whose spines were irradiated via para-aortic fields (34-37 Gy) prior to puberty. Two of 18 patients died from treatment complications and one from progressive disease.<bold>Conclusions: </bold>Multimodality treatment offers an excellent prognosis in paratesticular rhabdomyosarcoma, but is associated with significant morbidity and mortality rates. A discussion of therapy components and their application to disease stages suggests possible approaches to optimizing treatment for this therapy-sensitive malignancy.
- Publication
Cancer (0008543X), 1994, Vol 73, Issue 2, p476
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19940115)73:2<476::AID-CNCR2820730237>3.0.CO;2-N