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- Title
Prognostic significance of hormone receptors in endometrial cancer.
- Authors
Creasman, William T.; Creasman, W T
- Abstract
<bold>Background: </bold>Endometrial carcinoma is the most common female pelvic genital malignancy. Many studies suggest that approximately 75% of all endometrial cancers are clinical Stage I. More than 50% of cancer deaths are in patients with clinical Stage I disease. As a result, prognostic factors have been evaluated in an attempt to identify those patients with presumed early stage disease who will be at high risk for recurrence. Recently, hormone receptor status (estrogen [ER], progesterone [PR]) in endometrial cancer has been suggested to be a prognostic factor.<bold>Methods: </bold>Two hundred seventeen patients with Stage I and II endometrial cancers were evaluated for cytoplasmic steroid-receptor status. These results were compared with other prognostic factors in both univariant and multivariant analysis.<bold>Results: </bold>When ER and PR and combined ER/PR status were analyzed separately, patients with receptor-positive lesions had significantly better disease-free survival than those with receptor-negative lesions. The receptor status was also a significant independent prognostic factor when evaluated by stepwise proportional hazards regression analysis.<bold>Conclusions: </bold>Hormone receptor status in endometrial cancer appears to be an important prognostic factor.
- Publication
Cancer (0008543X), 1993, Vol 71, p1467
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.2820710411