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- Title
Conservation therapy for invasive lobular carcinoma of the breast.
- Authors
Poen, Joseph C.; Tran, Luu; Juillard, Guy; Selch, Michael T.; Giuliano, Armando; Silverstein, Melvin; Fingerhut, Aaron; Lewinsky, Bernard; Parker, Robert G.; Poen, J C; Tran, L; Juillard, G; Selch, M T; Giuliano, A; Silverstein, M; Fingerhut, A; Lewinsky, B; Parker, R G
- Abstract
Earlier literature suggests a high incidence of multicentricity and bilaterality, with an overall poor prognosis, in patients with invasive lobular carcinoma of the breast. Consequently, there is considerable disagreement regarding appropriate local management of this disease. To determine the influence of invasive lobular histologic findings on local tumor control, disease-free survival, and overall survival, the authors reviewed 60 patients with Stage I and II invasive lobular breast carcinoma treated with local tumor excision and radiation therapy between 1981 and 1987 (mean follow-up, 5.5 years; range, 2.5 to 10 years). The 5-year actuarial risk of locoregional recurrence was 5%, with two of three failures occurring in the regional lymphatics. The mean time to locoregional failure was 28 months. The 5-year actuarial disease-free survival (84%) and overall survival (91%) were comparable to those seen in several large series of similarly treated patients with invasive ductal carcinoma. Contralateral breast cancer occurred at a rate of approximately 0.6% per year. This study and a review of the literature suggest that breast conservation, with local resection and radiation therapy, is appropriate therapy for invasive lobular breast cancer.
- Subjects
BREAST tumor treatment; CANCER-related mortality; CANCER treatment; BREAST tumors; CANCER; LONGITUDINAL method; METASTASIS; MULTIPLE tumors; PROGNOSIS; RADIATION doses; RADIOGRAPHY; SURVIVAL; TUMOR classification
- Publication
Cancer (0008543X), 1992, Vol 69, Issue 11, p2789
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19920601)69:11<2789::AID-CNCR2820691126>3.0.CO;2-J