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- Title
Malignant fibrous histiocytoma of soft tissue. A population-based epidemiologic and prognostic study of 137 patients.
- Authors
Rööser, Bo; Willén, Helena; Gustafson, Pelle; Alvegård, Thor A.; Rydholm, Anders; Rööser, B; Willén, H; Gustafson, P; Alvegård, T A; Rydholm, A
- Abstract
Epidemiology and prognosis were analyzed in a consecutive, population-based series of 137 patients with malignant fibrous histiocytoma of soft tissue in the extremities and trunk wall, with a complete follow-up of minimum 3 years. All but one patient were treated by surgery in 28 cases combined with adjuvant radiotherapy or chemotherapy. The annual incidence was 0.42/10(5). The ratio men to women was 1.1. The median age was 64 years (range, 22 to 87 years). The thigh was the most common location. The median size was 6 cm. Superficial tumors constituted 43% and were smaller than deep-seated tumors. Eighty-three tumors were storiform-pleomorphic, 53 were myxoid, and one was of inflammatory type. The myxoid tumors were smaller and more often superficial. The cumulative 5-year survival rate for all patients was 0.7, but differed markedly between the histologic types; it was 1.0 in patients with myxoid tumors and 0.5 in patients with storiform-pleomorphic tumors. In the 77 patients with storiform-pleomorphic tumors without metastases at presentation, only tumor size larger than 10 cm and tumor necrosis independently impaired survival. The 23 patients who had none of these risk factors had a 5-year survival rate of 0.8.
- Publication
Cancer (0008543X), 1991, Vol 67, Issue 2, p499
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19910115)67:2<499::AID-CNCR2820670230>3.0.CO;2-E