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- Title
MiR-3910 Promotes the Growth and Migration of Cancer Cells in the Progression of Hepatocellular Carcinoma.
- Authors
Cheng, Lina; Wang, Hongwei; Han, Shuangyin
- Abstract
<bold>Introduction: </bold>Previous studies have reported that specific depletion of mammalian sterile-like kinase (MST1) in the mouse liver driven Hepatocellular carcinoma (HCC). However, how the expression of MST1 was regulated in the progression of HCC remains largely unknown.<bold>Materials and Methods: </bold>The expression of miR-3910 in the HCC tissues and cell lines were examined using q-PCR. The functions of miR-3910 in HCC were examined using MTT assay, Boyden chamber assay and soft agar assay. The effects of miR-3910 on the metastasis of HCC cells were evaluated using the mouse model.<bold>Results: </bold>Here, we have shown that miR-3910 regulated the expression of MST1. MiR-3910 was up-regulated in HCC samples and cell lines, and the expression of miR-3910 was induced by the oncogenic RasV12. In the functional study, miR-3910 was found to promote the growth and migration of HCC cells, and knocking down miR-3910 inhibited the metastasis of HCC cells. Mechanically, it was found that miR-3910 activated YAP signaling by targeting MST1.<bold>Conclusion: </bold>Taken together, this study demonstrated that miR-3910 exerted oncogenic effects on the progression of HCC and suggested that miR-3910 might be a therapeutic target for cancer therapy.
- Subjects
CANCER cells; CELL growth; CELL migration; LIVER cancer; KINASES; CELL lines; CANCER treatment
- Publication
Digestive Diseases & Sciences, 2017, Vol 62, Issue 10, p2812
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-017-4670-3