We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation and simplified measurement of infarct size by myocardial contrast echocardiography in a rat model of myocardial infarction.
- Authors
Xianghui Chen; Kai Cui; Jiancheng Xiu; Huanbing Lin; Yi Lao; Biying Zhou; Feixue Liang; Daogang Zha; Jianping Bin; Yili Liu
- Abstract
To test the feasibility and accuracy of myocardial contrast echocardiography (MCE) for predicting infarct size (IS) in a rat model of myocardial infarction (MI) and to compare a simplified single plane-based measurement of IS with the conventional three plane-based approach. Fifty male SD rats underwent left anterior descending artery ligation and were evaluated by MCE 8 h post MI. IS was calculated by the single and three plane-based approaches, compared to that determined by triphenyltetrazolium chloride (TTC) staining method. Simplified single plane-based MCE approach and TTC method showed similar IS values (38.48 ± 16.80% vs. 35.72 ± 15.33%, P > 0.05) and presented a favorable positive correlation ( r = 0.851, P < 0.001). IS values derived from simplified single plane-based approach was also highly significantly correlated with that by the conventional MCE method ( r = 0.973, P < 0.001). Bland–Altman plots also displayed satisfactory agreement between them. MCE was validated as a novel technique to quantify infarct area in rats with MI. A single measurement at the mid-papillary muscle level may become a simple, efficient and reliable approach for in vivo IS assessment.
- Subjects
MYOCARDIAL infarction; CARDIAC imaging; CORONARY disease; BLOOD vessels; ECHOCARDIOGRAPHY
- Publication
International Journal of Cardiovascular Imaging, 2009, Vol 25, Issue 7, p713
- ISSN
1569-5794
- Publication type
Article
- DOI
10.1007/s10554-009-9474-x