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- Title
SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the Loss of Primary Cilia.
- Authors
Li, Lianshun; Zhao, Huiming; Li, Zhengyang; Shi, Wengui; Jiao, Zuoyi
- Abstract
Primary cilia are microtubule-based organelles that mediate various biological processes. Pancreatic cells are typically ciliated; however, the role of primary cilia in acute pancreatitis (AP) is largely unknown. Here, we report that the loss of primary cilia, mediated by SHCBP1 (SHC1 binding protein), exerted a provocative effect on AP. Primary cilia are extensively lost in inflamed pancreatic cells in vitro and in mouse tissues with AP in vivo. Abrogation of primary cilia aggravated lipopolysaccharide (LPS)-induced inflammation in pancreatic cells. Mechanistically, AP induced the overexpression of SHCBP1 mitotic factor, which is localized to the base of primary cilia. SHCBP1 deficiency relieved LPS- and cerulein-induced pancreatitis by preventing the loss of primary cilia in vitro and in vivo. Collectively, we reveal that inflammation-induced loss of primary cilia aggravates AP. Furthermore, abrogating SHCBP1 to prevent primary cilia loss is an efficient strategy to combat AP.
- Subjects
CILIA &; ciliary motion; PANCREATITIS; GENETIC overexpression; CARRIER proteins
- Publication
DNA & Cell Biology, 2024, Vol 43, Issue 3, p141
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/dna.2023.0240