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- Title
Perineal Nodular Induration (“Biker’s Nodule”): Report of Two Cases With Fine-Needle Aspiration Cytology and Immunohistochemical Study.
- Authors
Khedaoui, Radia; Martín-Fragueiro, Luz M.; Tardío, Juan C.
- Abstract
Perineal nodular induration (PNI) is a fibroblastic pseudotumor that presents almost exclusively in male cyclists. It develops in the soft tissues of the perineum immediately posterior to the scrotum, as a bilateral or single, central or lateralized mass. Although well known to sport medicine specialists, it is a scarcely documented entity in the pathology literature. We present 2 cases of PNI with fine-needle aspiration cytology and immunohistochemistry. They consisted of a paucicellular fibroblastic proliferation containing CD34-reactive spindle and epithelioid cells, small foci of fibrinoid degeneration, numerous blood vessels, and entrapped groups of mature fat cells. Our cases show that the histopathological features of PNI are more varied than those previously described and its immunohistochemical profile is wider. A central cystic focus and a zonal pattern are not consistent features of this entity. The lesional cells can express CD34, a hitherto unreported immunohistochemical finding.
- Subjects
INTRACRANIAL hypertension; IMMUNOHISTOCHEMISTRY techniques; CYTOLOGICAL techniques; FIBROSARCOMA; NEOVASCULARIZATION; FAT cells; PHYSIOLOGY
- Publication
International Journal of Surgical Pathology, 2014, Vol 22, Issue 1, p71
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/1066896912465008