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- Title
Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation.
- Authors
Darmarajan, Thiviya; Paudel, Keshav Raj; Candasamy, Mayuren; Chellian, Jestin; Madheswaran, Thiagarajan; Sakthivel, Lakshmana Prabu; Goh, Bey Hing; Gupta, Piyush Kumar; Jha, Niraj Kumar; Devkota, Hari Prasad; Gupta, Gaurav; Gulati, Monica; Singh, Sachin Kumar; Hansbro, Philip Michael; Oliver, Brian Gregory George; Dua, Kamal; Chellappan, Dinesh Kumar
- Abstract
Coronavirus disease 2019 (COVID-19) is an infectious disease associated with the respiratory system caused by the SARS-CoV-2 virus. The aim of this review article is to establish an understanding about the relationship between autoimmune conditions and COVID-19 infections. Although majority of the population have been protected with vaccines against this virus, there is yet a successful curative medication for this disease. The use of autoimmune medications has been widely considered to control the infection, thus postulating possible relationships between COVID-19 and autoimmune diseases. Several studies have suggested the correlation between autoantibodies detected in patients and the severity of the COVID-19 disease. Studies have indicated that the SARS-CoV-2 virus can disrupt the self-tolerance mechanism of the immune system, thus triggering autoimmune conditions. This review discusses the current scenario and future prospects of promising therapeutic strategies that may be employed to regulate such autoimmune conditions.
- Subjects
COVID-19; AUTOIMMUNE diseases; AUTOANTIBODIES; RESPIRATORY diseases; SARS-CoV-2; IMMUNE system
- Publication
Environmental Science & Pollution Research, 2022, Vol 29, Issue 36, p54072
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-022-20984-7