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- Title
Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial.
- Authors
Ansari, Mehdi; Sadeghi, Parvane; Mahdavi, Hamid; Fattahi-Dolatabadi, Mohsen; Mohamadi, Neda; Asadi, Amir; Sharififar, Fariba
- Abstract
Background: Fenugreek seeds have shown antinociceptive effect in animal studies. This double-blind placebo controlled trial was designed to study the effect of fenugreek transdermal patch 10% (FDP) for management of inguinal hernia (IH) post-operative pain. Methods: Standardized extract of fenugreek seeds was used for FDP formulation. Ninety patients treated with 10% FDP, diclofenac dermal patch 1% (DP) and placebo twice daily after IH surgery. The pain intensity score was evaluated using a visual analogue score (VAS) up to 48 h after operation. Morphine consumption and diclofenac suppository demand were evaluated too. Results: The pain score was significantly reduced in FDP group in comparison with the placebo group. This effect was also significantly different from DP up to 6 h after surgery (p<0.05). Morphine consumption and diclofenc suppository demand were significantly decreased in FDP group (p<0.05). Conclusion: In all, results of the present study indicated that FDP decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch, and this preparation could be a suit option as a natural antinociceptive agent for pain management.
- Subjects
ANALGESICS; DRUG therapy; DICLOFENAC; INGUINAL hernia; MORPHINE; PAIN; POSTOPERATIVE pain; SEEDS; SUPPOSITORIES; TRANSDERMAL medication; PAIN management; PLANT extracts; PAIN measurement; RANDOMIZED controlled trials; VISUAL analog scale; BLIND experiment; THERAPEUTICS
- Publication
Journal of Complementary & Integrative Medicine, 2019, Vol 16, Issue 3, pN.PAG
- ISSN
1553-3840
- Publication type
Article
- DOI
10.1515/jcim-2018-0082