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- Title
Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion.
- Authors
Yoshida, Satoya; Yoshida, Tatsuya; Inukai, Kohei; Kato, Katsuhiro; Yura, Yoshimitsu; Hattori, Tomoki; Enomoto, Atsushi; Ohashi, Koji; Okumura, Takahiro; Ouchi, Noriyuki; Kawase, Haruya; Wettschureck, Nina; Offermanns, Stefan; Murohara, Toyoaki; Takefuji, Mikito
- Abstract
Chronic fibrotic tissue disrupts various organ functions. Despite significant advances in therapies, mortality and morbidity due to heart failure remain high, resulting in poor quality of life. Beyond the cardiomyocyte-centric view of heart failure, it is now accepted that alterations in the interstitial extracellular matrix (ECM) also play a major role in the development of heart failure. Here, we show that protein kinase N (PKN) is expressed in cardiac fibroblasts. Furthermore, PKN mediates the conversion of fibroblasts into myofibroblasts, which plays a central role in secreting large amounts of ECM proteins via p38 phosphorylation signaling. Fibroblast-specific deletion of PKN led to a reduction of myocardial fibrotic changes and cardiac dysfunction in mice models of ischemia-reperfusion or heart failure with preserved ejection fraction. Our results indicate that PKN is a therapeutic target for cardiac fibrosis in heart failure. Despite significant advances in therapies, mortality and morbidity resulting from heart failure remain high. Here, the authors show that fibroblast-specific deletion of Protein kinase N (PKN) reduces myocardial fibrotic changes, indicating PKN as a potential therapeutic target for heart failure.
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-52068-0