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- Title
Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing.
- Authors
Yan, Xiaojin; Yang, Fan; Lv, Guanghao; Qiu, Yuping; Jia, Xiaoying; Hu, Qirong; Zhang, Jia; Yang, Jing; Ouyang, Xiangyuan; Gao, Lingyan; Jia, Chuandong
- Abstract
Herein, we report a new strategy for the design of antibiotic agents based on the electrostatic interaction and hydrogen bonding, highlighting the significance of hydrogen bonding and the increased recognition sites in facilitating the interaction with bacterial cell membranes and DNA. A series of quaternary ammonium functionalized urea-based anion receptors were studied. While the monodentate mono-urea M1, bisurea M2, and trisurea M3 failed to break through the cell membrane barrier and thus could not kill bacteria, the extended bidentate dimers D1–D3 presented gradually increased membrane penetrating capabilities, DNA conformation perturbation abilities, and broad-spectrum antibacterial activities against E. coli, P. aeruginosa, S. aureus, E. faecalis, and S. epidermidis.
- Subjects
BACTERIAL cell membranes; BACTERIAL DNA; ESCHERICHIA coli; SUPRAMOLECULAR chemistry; HYDROGEN bonding interactions
- Publication
Molecules, 2024, Vol 29, Issue 16, p3937
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29163937