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- Title
Caveolin and NOS in the Development of Muscular Dystrophy.
- Authors
Nakashima, Moeka; Suga, Naoko; Yoshikawa, Sayuri; Matsuda, Satoru
- Abstract
Caveolin is a structural protein within caveolae that may be involved in transmembrane molecular transport and/or various intercellular interactions within cells. Specific mutations of caveolin-3 in muscle fibers are well known to cause limb–girdle muscular dystrophy. Altered expression of caveolin-3 has also been detected in Duchenne muscular dystrophy, which may be a part of the pathological process leading to muscle weakness. Interestingly, it has been shown that the renovation of nitric oxide synthase (NOS) in sarcolemma with muscular dystrophy could improve muscle health, suggesting that NOS may be involved in the pathology of muscular dystrophy. Here, we summarize the notable function of caveolin and/or NOS in skeletal muscle fibers and discuss their involvement in the pathology as well as possible tactics for the innovative treatment of muscular dystrophies.
- Subjects
DUCHENNE muscular dystrophy; MUSCULAR dystrophy; MUSCLE weakness; NITRIC-oxide synthases; CYTOSKELETAL proteins
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8771
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168771