We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Risk factors for development of sterile haemorrhagic cystitis in canine lymphoma patients receiving oral cyclophosphamide: a case-control study.
- Authors
Gaeta, R.; Brown, D.; Cohen, R.; Sorenmo, K.
- Abstract
Sterile haemorrhagic cystitis ( SHC) is a known risk of cyclophosphamide treatment; however, most canine reports are case series. This case-control study examined risk factors for SHC in dogs with lymphoma receiving oral cyclophosphamide. Twenty-two dogs with SHC and 66 control dogs were identified. On univariate analysis, SHC risk factors included age ( P = 0.041), induction protocol ( P = 0.021) and cumulative cyclophosphamide dose ( P = 0.002). On multivariate analysis, increasing cumulative cyclophosphamide dose was associated with increased risk of SHC and the 'short' induction protocol (protocol 1) was associated with decreased risk. Controlling for age and induction protocol, odds of SHC increased by 2.21 per 750 mg m−2 increase in cyclophosphamide dose ( P = 0.001). SHC from oral cyclophosphamide is a predominately delayed toxicity resulting from high cumulative doses.
- Subjects
CYSTITIS; CYCLOPHOSPHAMIDE; LYMPHOMAS; DRUG toxicity; UNIVARIATE analysis; MULTIVARIATE analysis
- Publication
Veterinary & Comparative Oncology, 2014, Vol 12, Issue 4, p277
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12009