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- Title
Tumor‐Microenvironment‐Induced Degradation of Ultrathin Gadolinium Oxide Nanoscrolls for Magnetic‐Resonance‐Imaging‐Monitored, Activatable Cancer Chemotherapy.
- Authors
Wu, Miaomiao; Xue, Yumeng; Li, Na; Zhao, Hongyang; Lei, Bo; Wang, Min; Wang, Jianwei; Luo, Meng; Zhang, Chao; Du, Yaping; Yan, Chunhua
- Abstract
The development of biodegradable inorganic nanoparticles with a tumor microenvironment‐activated therapeutic mode of action is urgently needed for precision cancer medicine. Herein, the synthesis of ultrathin lanthanide nanoscrolls (Gd2O3 NSs) is reported, which biodegrade upon encountering the tumor microenvironment. The Gd2O3 NSs showed highly controlled magnetic properties, which enabled their high‐resolution magnetic resonance imaging (MRI). Importantly, Gd2O3 NSs degrade in a pH‐responsive manner and selectively penetrate tumor tissue, enabling the targeted release of anti‐cancer drugs. Gd2O3 NSs can be efficiently loaded with an anti‐cancer drug (DOX, 80 %) and significantly inhibit tumor growth with negligible cellular and tissue toxicity both in vitro and in vivo. This study may provide a novel strategy to design tumor microenvironment‐responsive inorganic nanomaterials for biocompatible bioimaging and biodegradation‐enhanced cancer therapy.
- Subjects
TUMOR microenvironment; GADOLINIUM; MAGNETIC resonance imaging; CANCER treatment; RARE earth metals
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 21, p6954
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201812972