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- Title
(Dynamic) Kinetic Resolution of Enamines/Imines: Enantioselective N‐Heterocyclic Carbene Catalyzed [3+3] Annulation of Bromoenals and Enamines/Imines.
- Authors
Chen, Kun‐Quan; Gao, Zhong‐Hua; Ye, Song
- Abstract
The enantioselective N‐heterocyclic carbene catalyzed [3+3] annulation of α‐bromoenals by dynamic kinetic resolution (DKR) of enamines and normal resolution of α,α‐disubstituted imines were developed. The corresponding substituted dihydropyridones were isolated in good yields with excellent diastereo‐ and enantioselectivities, and a high selective factor (up to 83) was realized for the resolution of α,α‐disubstituted imines.
- Subjects
ENANTIOSELECTIVE catalysis; ENAMINES; IMINES; CARBENES; ANNULATION; CHEMICAL kinetics
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 4, p1195
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201813047