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- Title
Metal-Free Intermolecular Aminoarylation of Alkynes.
- Authors
Rabet, Pauline T. G.; Boyd, Scott; Greaney, Michael F.
- Abstract
A metal-free aminoarylation of internal alkynes is described, yielding tetrasubstituted enaminoates. The transformation proceeds in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl and heteroaryl sulfonamides. Substrate scope is very broad under simple, user-friendly conditions, and the reaction can be used to easily access biologically active phenethylamine derivatives.
- Subjects
INTERMOLECULAR interactions; ALKYNES; CHEMICAL yield; SULFONAMIDES; BIOCHEMICAL substrates
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 15, p4247
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201612445