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- Title
Anaerobe-Inspired Anticancer Nanovesicles.
- Authors
Qian, Chenggen; Feng, Peijian; Yu, Jicheng; Chen, Yulei; Hu, Quanyin; Sun, Wujin; Xiao, Xuanzhong; Hu, Xiuli; Bellotti, Adriano; Shen, Qun‐Dong; Gu, Zhen
- Abstract
Anaerobic bacteria, such as Clostridium and Salmonella, can selectively invade and colonize in tumor hypoxic regions (THRs) and deliver therapeutic products to destroy cancer cells. Herein, we present an anaerobe nanovesicle mimic that can not only be activated in THRs but also induce hypoxia in tumors by themselves. Moreover, inspired by the oxygen metabolism of anaerobes, we construct a light-induced hypoxia-responsive modality to promote dissociation of vehicles and activation of bioreductive prodrugs simultaneously. In vitro and in vivo experiments indicate that this anaerobe-inspired nanovesicle can efficiently induce apoptotic cell death and significantly inhibit tumor growth. Our work provides a new strategy for engineering stimuli-responsive drug delivery systems in a bioinspired and synergistic fashion.
- Subjects
ANTINEOPLASTIC agents; CLOSTRIDIUM; SALMONELLA; CANCER cells; HYPOXIA-inducible factors; HYPOXEMIA; TUMOR growth prevention
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 10, p2632
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201611783