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- Title
Construction of Quaternary Stereocenters by Nickel-Catalyzed Heck Cyclization Reactions.
- Authors
Desrosiers, Jean ‐ Nicolas; Hie, Liana; Biswas, Soumik; Zatolochnaya, Olga V.; Rodriguez, Sonia; Lee, Heewon; Grinberg, Nelu; Haddad, Nizar; Yee, Nathan K.; Garg, Neil K.; Senanayake, Chris H.
- Abstract
A nickel-catalyzed Heck cyclization for the construction of quaternary stereocenters is reported. This transformation is demonstrated in the synthesis of 3,3-disubstituted oxindoles, which are prevalent motifs seen in numerous biologically active molecules. The method shows broad scope, proceeds in synthetically useful yields, and provides a rare means to construct stereochemically complex frameworks by nonprecious-metal catalysis.
- Subjects
NICKEL catalysts; RING formation (Chemistry); CHEMICAL reactions; OXINDOLES; CHEMICAL yield
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 39, p12100
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201606955