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- Title
Transition-Metal-Free α-Arylation of Enolizable Aryl Ketones and Mechanistic Evidence for a Radical Process.
- Authors
Pichette Drapeau, Martin; Fabre, Indira; Grimaud, Laurence; Ciofini, Ilaria; Ollevier, Thierry; Taillefer, Marc
- Abstract
The α-arylation of enolizable aryl ketones can be carried out with aryl halides under transition-metal-free conditions using KO tBu in DMF. The α-aryl ketones thus obtained can be used for step- and cost-economic syntheses of fused heterocycles and Tamoxifen. Mechanistic studies demonstrate the synergetic role of base and solvent for the initiation of the radical process.
- Subjects
TRANSITION metals; ARYLATION; KETONES; ARYL halides; HETEROCYCLIC compounds synthesis; TAMOXIFEN
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 36, p10733
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201502332