We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Controlling the Origins of Inflammation with a Photoactive Lipopeptide Immunopotentiator.
- Authors
Mancini, Rock J.; Stutts, Lalisa; Moore, Troy; Esser-Kahn, Aaron P.
- Abstract
Inflammatory immune responses are mediated by signaling molecules that are both produced by and recognized across highly heterogeneous cell populations. Assuch, the study of inflammation using traditional immunostimulants is complicated by paracrine and autocrine signaling, which obscures the origin of apropagating response. To address this challenge, we developed a small-molecule probe that can photosensitizeimmune cells, thus allowing light-mediated inflammation. This probe was used to control the origin of inflammation using light. Following this motif, inflammation was initiated from fibroblasts or dendritic cells. The contributions of fibroblasts and dendritic cells in initiating inflammation in heterogeneous co-culture are reported, thus providing insights into the future development of vaccines and treatment of inflammation.
- Subjects
IMMUNOLOGICAL adjuvants; INFLAMMATION; LIGHT-activated pesticides; LIPOPEPTIDE antibiotics; AUTOCRINE mechanisms
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 20, p6060
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201500416