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- Title
Rationally Designed Multifunctional Supramolecular Iminium Catalysis: Direct Vinylogous Michael Addition of Unmodified Linear Dienol Substrates.
- Authors
Gu, Yun; Wang, Yao; Yu, Tian ‐ Yang; Liang, Yong ‐ Min; Xu, Peng ‐ Fei
- Abstract
The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to α,β-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.
- Subjects
SUPRAMOLECULAR chemistry; MICHAEL reaction; IMINIUM compounds; ASYMMETRIC synthesis; REGIOSELECTIVITY (Chemistry)
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 51, p14352
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201406786