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- Title
NIR-II Fluorescent Probes for Fluorescence-Imaging-Guided Tumor Surgery.
- Authors
Ullah, Zia; Roy, Shubham; Gu, Jingshi; Ko Soe, Sai; Jin, Jian; Guo, Bing
- Abstract
Second near-infrared (NIR-II) fluorescence imaging is the most advanced imaging fidelity method with extraordinary penetration depth, signal-to-background ratio, biocompatibility, and targeting ability. It is currently booming in the medical realm to diagnose tumors and is being widely applied for fluorescence-imaging-guided tumor surgery. To efficiently execute this modern imaging modality, scientists have designed various probes capable of showing fluorescence in the NIR-II window. Here, we update the state-of-the-art NIR-II fluorescent probes in the most recent literature, including indocyanine green, NIR-II emissive cyanine dyes, BODIPY probes, aggregation-induced emission fluorophores, conjugated polymers, donor–acceptor–donor dyes, carbon nanotubes, and quantum dots for imaging-guided tumor surgery. Furthermore, we point out that the new materials with fluorescence in NIR-III and higher wavelength range to further optimize the imaging results in the medical realm are a new challenge for the scientific world. In general, we hope this review will serve as a handbook for researchers and students who have an interest in developing and applying fluorescent probes for NIR-II fluorescence-imaging-guided surgery and that it will expedite the clinical translation of the probes from bench to bedside.
- Subjects
FLUORESCENT probes; TUMOR surgery; CONJUGATED polymers; CYANINES; INDOCYANINE green; QUANTUM dots; CARBON nanotubes
- Publication
Biosensors (2079-6374), 2024, Vol 14, Issue 6, p282
- ISSN
2079-6374
- Publication type
Article
- DOI
10.3390/bios14060282