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- Title
Statin-induced, immune-mediated necrotising myopathy triggered by malignancy successfully treated with immunosuppression.
- Authors
Abouelazm, Ahmed; Philops, Kirollos; Amine, Amr; Golam, Yahia
- Abstract
Statin-induced immune-mediated necrotising myopathy (IMNM) is an inflammatory myopathy that can present as proximal muscle weakness and, in some cases, as dysphagia and respiratory distress. In this report, we present a case of statin-induced IMNM in a 78-year-old male. The patient had significantly high levels of creatinine kinase and myoglobinuria and experienced gradual weakness in the proximal muscles for 1 month after initiating a 20 mg dose of Atorvastatin 10 months before admission. Rapid clinical improvement was observed with the use of high-dose glucocorticoids in conjunction with methotrexate.
- Subjects
AUTOIMMUNE disease diagnosis; IMMUNOSUPPRESSIVE agents; MUSCLE diseases; METHOTREXATE; MUSCLE weakness; ATORVASTATIN; CREATINE kinase; AUTOIMMUNE diseases; STATINS (Cardiovascular agents); GLUCOCORTICOIDS
- Publication
Clinical Medicine, 2024, Vol 24, Issue 3, p1
- ISSN
1470-2118
- Publication type
Article
- DOI
10.1016/j.clinme.2024.100217