We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Factors Governing B Cell Recognition of Autoantigen and Function in Type 1 Diabetes.
- Authors
Bass, Lindsay E.; Bonami, Rachel H.
- Abstract
Islet autoantibodies predict type 1 diabetes (T1D) but can be transient in murine and human T1D and are not thought to be directly pathogenic. Rather, these autoantibodies signal B cell activity as antigen-presenting cells (APCs) that present islet autoantigen to diabetogenic T cells to promote T1D pathogenesis. Disrupting B cell APC function prevents T1D in mouse models and has shown promise in clinical trials. Autoantigen-specific B cells thus hold potential as sophisticated T1D biomarkers and therapeutic targets. B cell receptor (BCR) somatic hypermutation is a mechanism by which B cells increase affinity for islet autoantigen. High-affinity B and T cell responses are selected in protective immune responses, but immune tolerance mechanisms are known to censor highly autoreactive clones in autoimmunity, including T1D. Thus, different selection rules often apply to autoimmune disease settings (as opposed to protective host immunity), where different autoantigen affinity ceilings are tolerated based on variations in host genetics and environment. This review will explore what is currently known regarding B cell signaling, selection, and interaction with T cells to promote T1D pathogenesis.
- Subjects
AUTOIMMUNE diseases; CELLULAR recognition; TYPE 1 diabetes; B cells; B cell receptors; T cells
- Publication
Antibodies (2073-4468), 2024, Vol 13, Issue 2, p27
- ISSN
2073-4468
- Publication type
Article
- DOI
10.3390/antib13020027