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- Title
A randomized, double-blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally.
- Authors
Solomon, Todd M.; Leech, Jarrett; deBros, Guy B.; Murphy, Cynthia A.; Budson, Andrew E.; Vassey, Elizabeth A.; Solomon, Paul R.
- Abstract
Objective Alpha BRAIN® is a nootropic supplement that purports to enhance cognitive functioning in healthy adults. The goal of this study was to investigate the efficacy of this self-described cognitive enhancing nootropic on cognitive functioning in a group of healthy adults by utilizing a randomized, double blind, placebo-controlled design. Methods A total of 63-treatment naïve individuals between 18 and 35 years of age completed the randomized, double-blind, placebo controlled trial. All participants completed a 2-week placebo run in before receiving active product, Alpha BRAIN® or new placebo, for 6 weeks. Participants undertook a battery of neuropsychological tests at randomization and at study completion. Primary outcome measures included a battery of neuropsychological tests and measures of sleep. Results Compared with placebo, Alpha BRAIN® significantly improved on tasks of delayed verbal recall and executive functioning. Results also indicated significant time-by-group interaction in delayed verbal recall for the Alpha BRAIN® group. Conclusions The use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study.
- Subjects
NOOTROPIC agents; COGNITIVE ability; RANDOMIZED controlled trials; NEUROPSYCHOLOGICAL tests; PLACEBOS
- Publication
Human Psychopharmacology: Clinical & Experimental, 2016, Vol 31, Issue 2, p135
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.2520