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- Title
Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats
- Authors
Brondani, Juliana T.; Luna, Stelio P.L.; Marcello, Gracy C.G.; Padovani, Carlos R.
- Abstract
A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5mg/kg PO (V), tramadol 2mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0±0.32kg; 1.8±0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats.
- Subjects
DRUG administration; ANTI-inflammatory agents; ANALGESICS; BLOOD platelet aggregation; HEMORRHAGE; CAT diseases; PLACEBOS; DRUG design
- Publication
Journal of Feline Medicine & Surgery, 2009, Vol 11, Issue 6, p503
- ISSN
1098-612X
- Publication type
Article
- DOI
10.1016/j.jfms.2008.12.003