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- Title
Dynamic contrast-enhanced MRI, diffusion-weighted MRI and <sup>18</sup>F-FDG PET/CT for the prediction of survival in oropharyngeal or hypopharyngeal squamous cell carcinoma treated with chemoradiation.
- Authors
Ng, Shu-Hang; Liao, Chun-Ta; Lin, Chien-Yu; Chan, Sheng-Chieh; Lin, Yu-Chun; Yen, Tzu-Chen; Chang, Joseph; Ko, Sheung-Fat; Fan, Kang-Hsing; Wang, Hung-Ming; Yang, Lan-Yan; Wang, Jiun-Jie; Chang, Joseph Tung-Chieh
- Abstract
<bold>Objectives: </bold>We prospectively investigated the roles of pretreatment dynamic contrast-enhanced MR imaging (DCE-MRI), diffusion-weighted MR imaging (DWI) and 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG PET)/CT for predicting survival of oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) patients treated with chemoradiation.<bold>Methods: </bold>Patients with histologically proven OHSCC and neck nodal metastases scheduled for chemoradiation were eligible. Clinical variables as well as DCE-MRI-, DWI- and 18F-FDG PET/CT-derived parameters of the primary tumours and metastatic neck nodes were analysed in relation to 3-year progression-free survival (PFS) and overall survival (OS) rates.<bold>Results: </bold>Eighty-six patients were available for analysis. Multivariate analysis identified the efflux rate constant (K ep)-tumour < 3.79 min-1 (P = 0.001), relative volume of extracellular extravascular space (V e)-node < 0.23 (P = 0.004) and SUVmax-tumour > 19.44 (P = 0.025) as independent risk factors for both PFS and OS. A scoring system based upon the sum of each of the three imaging parameters allowed stratification of our patients into three groups (patients with 0/1 factor, patients with 2 factors and patients with 3 factors, respectively) with distinct PFS (3-year rates = 72 %, 38 % and 0 %, P < 0.0001) and OS (3-year rates = 81 %, 46 % and 20 %, P < 0.0001).<bold>Conclusions: </bold>K ep-tumour, V e-node and SUVmax-tumour were independent prognosticators for OHSCC treated with chemoradiation. Their combination helped survival stratification.<bold>Key Points: </bold>• K ep -tumour, V e -node and SUV max -tumour are independent predictors of survival rates. • The combination of these three prognosticators may help stratification of survival. • MRI and FDG-PET/CT play complementary roles in prognostication of head and neck cancer.
- Subjects
MAGNETIC resonance imaging; DIFFUSION magnetic resonance imaging; SQUAMOUS cell carcinoma; HEAD &; neck cancer; CANCER; COMPARATIVE studies; DEOXY sugars; DIAGNOSTIC imaging; RESEARCH methodology; HEAD tumors; MEDICAL cooperation; PROGNOSIS; RADIOPHARMACEUTICALS; NECK tumors; RESEARCH; POSITRON emission tomography; EVALUATION research; HYPOPHARYNX; OROPHARYNGEAL cancer; DIAGNOSIS; CANCER treatment; TUMOR treatment; TUMORS
- Publication
European Radiology, 2016, Vol 26, Issue 11, p4162
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4276-8