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- Title
Whole-body MRI in adult inflammatory myopathies: Do we need imaging of the trunk?
- Authors
Filli, Lukas; Maurer, Britta; Manoliu, Andrei; Andreisek, Gustav; Guggenberger, Roman
- Abstract
<bold>Objective: </bold>To evaluate whether imaging of the trunk could be omitted in patients with inflammatory myopathies without losing diagnostic accuracy using a restricted whole-body magnetic resonance imaging (rWB-MRI) protocol.<bold>Methods: </bold>After approval by the institutional review board, this study was performed in 63 patients (male/female, 13/50; median age, 52 years; range, 20-81 years) with new-onset myopathic symptoms (group 1, n = 41) or previously diagnosed inflammatory myopathy (group 2, n = 22). After performing whole-body MRI (WB-MRI) at 3.0 Tesla, myositis and fatty atrophy were evaluated in different muscles by two independent radiologists. The intra-class correlation coefficient (ICC) was calculated to evaluate inter-observer reliability.<bold>Results: </bold>Acquisition time was 56:01 minutes for WB-MRI and 37:37 minutes (32.8 % shorter) for rWB-MRI. In group 1, 14 patients were diagnosed with inflammatory myopathy based on muscle biopsy. rWB-MRI and WB-MRI showed equal sensitivity (42.9 %) and specificity (100 %) for myositis, and showed equal sensitivity (71.4 %) and similar specificity (63.0 % and 48.1 %, respectively) for fatty atrophy. No myositis was found in the body trunk in any patient. Inter-observer reliability was between substantial and perfect (ICC, 0.77-1.00).<bold>Conclusions: </bold>rWB-MRI showed diagnostic accuracy similar to WB-MRI for inflammatory myopathy at markedly reduced overall acquisition time.<bold>Key Points: </bold>• Whole-body MRI (WB-MRI) is a time-consuming imaging modality. • A shortened MRI protocol was evaluated for inflammatory myopathies. • The proposed protocol showed diagnostic accuracy similar to WB-MRI.
- Subjects
BIOPSY; DIAGNOSTIC imaging; MAGNETIC resonance imaging; MYOSITIS; RESEARCH evaluation; RESEARCH bias; CHEST (Anatomy)
- Publication
European Radiology, 2015, Vol 25, Issue 12, p3499
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-3783-3