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- Title
The association of haemoglobin A levels with the clinical and CT characteristics of Klebsiella pneumoniae liver abscesses in patients with diabetes mellitus.
- Authors
Wang, Hong-Hau; Tsai, Shih-Hung; Yu, Chih-Yung; Hsu, Hsian-He; Liu, Chang-Hsien; Lin, Jung-Chung; Huang, Guo-Shu; Cheng, Wei-Tung; Tung, Ho-Jui; Chen, Ching-Yang; Chang, Wei-Chou
- Abstract
Objectives: To compare the characteristics of Klebsiella pneumoniae liver abscesses (KPLA) in diabetic patients with different levels of glycaemic control. Methods: The institutional review board approved this retrospective study. A total of 221 patients with KPLA were included. Clinical features of KPLA were compared. We divided the 120 diabetic patients with KPLA into three subgroups based on haemoglobin A (HbA) concentration (good, HbA ≤ 7.0 %; suboptimal, 7.0 % < HbA ≤ 9.0 %; poor, HbA > 9.0 %). In this study, we used a semiautomated quantitative method to assess the gas and total abscess volumes in KPLA. Statistical analysis was performed with the chi-squared test and one-way analysis of variance. Results: The mortality rate did not significantly differ between the nondiabetic and diabetic groups. However, patients with poor glycaemic control had significantly more complications and therefore a longer hospital stay ( P < 0.05). In our study, CT and quantitative analyses found that patients in the group with poor glycaemic control had a significantly higher incidence of gas formation and hepatic venous thrombophlebitis and a higher gas-to-abscess volume ratio than patients with suboptimal and good glycaemic control ( P < 0.05). Conclusions: Diabetic patients with a high HbA concentration (>9.0 %) have an association with hepatic venous thrombophlebitis, gas formation and metastatic infection complications associated with KPLA. Key Points: • Poorly controlled diabetes is associated with complications in Klebsiella pneumoniae liver abscesses. • Hepatic venous thrombosis and gas are important signs of metastatic infection. • Hepatic venous thrombophlebitis is associated with 72.7 % of metastatic infections.
- Subjects
REGULATION of hemoglobin synthesis; KLEBSIELLA pneumoniae; LIVER abscesses; PEOPLE with diabetes; DIABETES complications; COMPUTED tomography; DIAGNOSIS; PHYSIOLOGY
- Publication
European Radiology, 2014, Vol 24, Issue 5, p980
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-014-3113-1