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- Title
Independent Requirements for 'Crithidia Factor' and Folk Acid in a Trypanosomid Flagellate.
- Authors
NATHAN, H. A.; HUTNER, S. H.; LEVIN, H. L.
- Abstract
THE trypanosomid parasite of mosquitoes, Crithidia fasciculata Anopheles strain (ATCC 11745), when grown in a defined medium1, required for growth unusually high levels of folic acid. In the presence of 'crithidia factor' (an unconjugated pteridine), much lower concentrations of folic acid supported growth; indeed, at times a separate folic acid requirement was not demonstrable2,3. Our collaborators at the American Cyanamid Co. have identified the crithidia factor in human urine as 2:NH2,4:OH,6-dihydroxypropyl pteridine3. In our experiments reported here, both the 6-dihydroxypropyl and a partially purified sample of the 6-trihydroxypropyl pteridine (generously supplied by Dr. E. L. Patterson) were used.
- Publication
Nature, 1956, Vol 178, Issue 4536, p741
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/178741a0