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- Title
Pulse wave velocity a useful tool for cardiovascular surveillance in pre-dialysis patients.
- Authors
Marcelo M. Lemos; Alessandra D. B. Jancikic; Fabiana M. R. Sanches; Dejaldo M. Christofalo; Sérgio A. Ajzen; Márcio H. Miname; Raul D. Santos; Fernando C. Fachini; Aluízio B. Carvalho; Sérgio A. Draibe; Maria Eugênia F. Canziani
- Abstract
Background. Cardiovascular mortality is high among patients with chronic kidney disease. Pulse wave velocity (PWV) is a simple method used for arterial distensibility evaluation. Few data are available concerning PWV in pre-dialysis patients. The aim of this study was to evaluate the association between PWV and cardiovascular disease in pre-dialysis. Methods. One hundred and four patients were submitted to PWV analysis, coronary artery calcium (CAC) determination with a multi-slice CT scan of the coronary arteries, echocardiogram and a carotid intima-media thickness (IMT) evaluation, with a high resolution ultrasound. The demographic characteristics and laboratory tests results were studied. Results. The mean age of those studied was 54.4 ± 11.5 years, 60% were males and the mean creatinine clearance was 40 ml/min/1.73 m2. The mean PWV was 12.2 ± 3.4 m/s and it was significantly higher in males, diabetics, those with creatinine clearance R = 0.48; P R = 0.50; P vs 10.7 ± 2.4 m/s; P R = 0.25; P = 0.01) while no association could be seen between PWV and the ejection fraction or left ventricular dysfunction. A correlation between the IMT and PWV was observed (R = 0.27; P = 0.005). In addition, those with a thicker IMT had a higher PWV (13.2 ± 3.4 m/s vs 11. 2 ± 3.2 m/s; P = 0.003). Conclusion. PWV is associated with cardiovascular disease in pre-dialysis patients and can be a useful tool to identify patients with increased cardiovascular risk.
- Subjects
HEMODIALYSIS patients; KIDNEY diseases; ECHOCARDIOGRAPHY; CREATININE
- Publication
Nephrology Dialysis Transplantation, 2007, Vol 22, Issue 12, p3527
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfm484