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- Title
Advanced glycation and lipoxidation end products: reactive carbonyl compounds‐related uraemic toxicity.
- Authors
Miyata, Toshio; Saito, Akira; Kurokawa, Kiyoshi; de Strihou, Charles van Ypersele
- Abstract
Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis‐related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non‐enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.
- Publication
Nephrology Dialysis Transplantation, 2001, Vol 16, p8
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/16.suppl_4.8