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- Title
Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi.
- Authors
Sharma, Vishal; Panjgotra, Shivali; Sharma, Nisha; Abrol, Vidushi; Goutam, Umesh; Jaglan, Sundeep
- Abstract
Scientists are making efforts to search for new metabolites as they are essential lead molecules for the drug discovery, much required due to the evolution of multi drug resistance and new diseases. Moreover, higher production of known drugs is required because of the ever growing population. Microorganisms offer a vast collection of chemically distinct compounds that exhibit various biological functions. They play a crucial role in safeguarding crops, agriculture, and combating several infectious ailments and cancer. Research on fungi have grabbed a lot of attention after the discovery of penicillin, most of the compounds produced by fungi under normal cultivation conditions are discovered and now rarely new compounds are discovered. Treatment of fungi with the epigenetic modifiers has been becoming very popular since the last few years to boost the discovery of new molecules and enhance the production of already known molecules. Epigenetic literally means above genetics that actually does not alter the genome but alter its expression by altering the state of chromatin from heterochromatin to euchromatin. Chromatin in heterochromatin state usually doesn't express because it is closely packed by histones in this state. Epigenetic modifiers loosen the packing of chromatin by inhibiting DNA methylation and histone deacetylation and thus permit the expression of genes that usually remain dormant. This study delves into the possibility of utilizing epigenetic modifying agents to generate pharmacologically significant secondary metabolites from fungi.
- Subjects
METABOLITES; EPIGENETICS; DRUG discovery; TRANSMISSIBLE tumors; EUCHROMATIN; HYDROXAMIC acids
- Publication
Biotechnology Letters, 2024, Vol 46, Issue 3, p297
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-024-03478-z