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- Title
Use of Dimethylsilyl Ethers for Characterizing Primary Aliphatic Alcohols: A comparison of mass spectrometric fragmentation of di- and trimethylsilyl derivatives.
- Authors
Richter, Wilhelm J.; Hunnemann, Don H.
- Abstract
Mass spectral fragmentation patterns of dimethylsilyl (DMS) ethers of primary unbranched, branched, and secondary unbranched aliphatic alcohols in the C5 to C10 range are compared with those of the corresponding trimethylsilyl (TMS) derivatives. Unlike their TMS analogues, DMS ethers of primary alcohols exhibit pronounced rupture of the CC bond adjacent to the oxygen atom within the alkyl moiety (loss of an alkyl radical R) in marked preference to cleavage within the silyl substituent (loss of CH3). Within this class of compounds, complementary preparation of DMS derivatives can therefore be used to establish or to confirm the site, and thus the primary nature of the hydroxyl group, whereas preparation of TMS ethers may be of advantage in deducing molecular size. For the derivatives of secondary alcohols this diagnostically useful difference in fragmentation behaviour is not observed.
- Publication
Helvetica Chimica Acta, 1974, Vol 57, Issue 4, p1131
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19740570420