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- Title
Insecticidal activity and mode of action of 2,4-diaminopyrimidines
- Authors
Dybas, J. A.; Peake, C. J.; Henrie, R. N., II; Cullen, R. G.; Plummer, M. J.; Wierenga, J. M.
- Abstract
Three 2,4-diaminopyrimidines were tested against several insect species. They were active against lepidopteran pests with LC50values <3 mg liter-1 for most species tested. They were also active against two-spotted spider mite, Tetranychus urticae, (LC50 10-40 mg liter-1). Folinate, but not hypoxanthine or thymidine was found to be an effective rescue agent, requiring a concentration of 100 mg liter-1 diet to rescue half of the intoxicated larvae. The results confirm dihydrofolate reductase to be the site of action for these insecticides and are consistent with the modeof action of folinate rescue in mammals.
- Subjects
FOLINIC acid; INSECTICIDES; PEST control
- Publication
Pest Management Science, 2000, Vol 56, Issue 3, p233
- ISSN
1526-498X
- Publication type
Article