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- Title
ÍNDICE TRIGLICÉRIDES-GLICOSE E HIPERURICEMIA COMO MARCADORES DE DESFECHOS CARDIOVASCULARES ADVERSOS: REVISÃO NARRATIVA.
- Authors
Marcos Girardi, José; Silva, Thiago; Nicolato Almada, Lucas; Moreira da Silva, Ramon José; Cotrim de Freitas, Allan Emerique; Araújo Girardi, Flávia
- Abstract
Introduction: Coronary artery disease and stroke due to atherosclerosis are causes of morbidity and mortality, characterized by endothelial dysfunction, calcification and arterial obstruction. Although optimized strategies for drug treatment and revascularization are implemented, there is still a high incidence of recurrent events. Insulin resistance is characterized by reduced insulin sensitivity in insulin-dependent organs and tissues and implies a high risk of atherosclerotic disease. The triglycerideglucose index has been proposed to identify insulin resistance. Hyperuricemia increases oxidative stress, smooth muscle cell proliferation and release of pro-inflammatory substances with endothelial damage. Objective: To conduct a narrative literature review to evaluate the role of the index as a marker of insulin resistance and its relationship with hyperuricemia in the identification of patients at higher cardiovascular risk. Methodology: Bibliographic search of articles in May 2023 using the health descriptors in English: "trygliceride-glucose index" AND "hyperuricemia" AND "coronary artery disease", published between May 2022 and May 2023, identifying articles available with open access, in the PubMed Central database. Results: Out of 34 articles found, 5 that did not meet the research were excluded, leaving 28 publications in the end. The triglycerideglucose index has been proposed to predict insulin resistance, can be reliable in terms of sensitivity/specificity, and can predispose to hyperuricemia. Conclusion: A higher value of the index was associated with an increased risk of cardiovascular events and mortality in the general population. Hyperuricemia is a biomarker for metabolic and cardiovascular disease, correlating with beta cell function, insulin resistance, decline in glomerular filtration rate, and cardiovascular disease.
- Subjects
INSULIN sensitivity; INSULIN resistance; CORONARY artery disease; LITERATURE reviews; ARTERIAL occlusions; BIBLIOGRAPHIC databases
- Publication
Revista Foco (Interdisciplinary Studies Journal), 2023, Vol 16, Issue 12, p1
- ISSN
1981-223X
- Publication type
Article
- DOI
10.54751/revistafoco.v16n12-155