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- Title
From the Cell Membrane to the Nucleus: Unearthing Transport Mechanisms for Dynein.
- Authors
Crossley, Laurie; Garrett, Caroline; Hafezparast, Majid; Madzvamuse, Anotida
- Abstract
Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed. We sought to develop a novel model which could incorporate the effects of mutations on distance travelled and velocity. A mechanical model for the dynein mediated transport of endosomes is derived from first principles and solved numerically. The effects of variations in model parameter values are analysed to find those that have a significant impact on velocity and distance travelled. The model successfully describes the processivity of dynein and matches qualitatively the velocity profiles observed in experiments.
- Subjects
DYNEIN; PROTEIN transport; BIOLOGICAL mathematical modeling; CELL membranes; MOLECULAR motor proteins; CHARCOT-Marie-Tooth disease; SPINAL muscular atrophy; ENDOCYTOSIS
- Publication
Bulletin of Mathematical Biology, 2012, Vol 74, Issue 9, p2032
- ISSN
0092-8240
- Publication type
Article
- DOI
10.1007/s11538-012-9745-x