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- Title
The Effectiveness of Oral Immunotherapy in Patients with Sesame Anaphylaxis using Omalizumab.
- Authors
Salari, Fereshteh; Bemanian, Mohammad Hassan; Fallahpour, Morteza; Mahdaviani, Seyed Alireza; Shokri, Sima; Khoshmirsafa, Majid; Seif, Farhad; Nabavi, Mohammad; Arshi, Saba
- Abstract
Objective: Sesame allergy is the most prevalent allergy to seeds. Oral immunotherapy (OIT) is defined as continuous consumption of an allergen at special doses and time. Omalizumab (Anti-IgE) increases tolerance to allergens used in OIT. This study evaluated the effectiveness of a new sesame OIT protocol in patients with sesame anaphylaxis in combination with omalizumab. Methods: In this prospective open-label interventional trial study, 11 patients with a history of sesame anaphylaxis were enrolled after confirmation by oral food challenge (OFC) test. At baseline, skin prick test (SPT) and skin prick to prick (SPP) test were performed. Serum sesame-specific IgE (sIgE) levels were measured. The maintenance phase was continued at home with daily sesame intake for 4 months. At the end of month 4, the OFC and above-mentioned tests were repeated to evaluate the treatment effectiveness. Results: All 11 patients who underwent sesame OIT after 4 months could tolerate a dietary challenge of 22 ml tahini (natural sesame seed, equal to 5,000 mg of sesame protein and higher) and the average of wheal diameter in the SPT and SPP tests significantly decreased after desensitization. Conclusion: This OIT protocol may be a promising desensitization strategy for patients with sesame anaphylaxis. Also, omalizumab appears to have reduced the severity of reactions.
- Subjects
ANAPHYLAXIS; ALLERGY desensitization; COMBINATION drug therapy; CLINICAL trials; ORAL drug administration; MONOCLONAL antibodies; TREATMENT effectiveness; SESAME oil; IMMUNOTHERAPY; FOOD allergy; LONGITUDINAL method
- Publication
Clinical Medicine & Research, 2022, Vol 20, Issue 3, p125
- ISSN
1539-4182
- Publication type
Article
- DOI
10.3121/cmr.2022.1730