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- Title
Polikistik over sendromunda disfonksiyonel HDL'nin göstergesi olarak miyeloperoksidaz/paraoksonazl oranının değerlendirilmesi.
- Authors
KOC, ESİN MERVE EROL; YAMAN, SELEN; CEYHAN, MERYEM; NESELİOGLU, SALİM; EREL, OZCAN; DOGANAY, MELİKE
- Abstract
Aim: The myeloperoxidase/paraoxonase1(MPO/PON1) ratio is known to reflect the dysfunctional HDL(d-HDL) which is a measure of oxidative stress. This study aimed to evaluate the MPO/PON1 ratio in polycystic ovary syndrome(PCOS). Materials and Method: This prospective study included a total of 123 patients. The study group including the women with the diagnosis of PCOS (n=63) was compared to the control group including the healthy women (n=60). Sociodemographic chara cteristics, and clinical features of the groups were recorded. Serum HDL level, MPO, and PON1 activitieswere evaluated. Results: The PCOS patients were observed to have increased MPO and decreased PON1 activities (p<0.0001 and p=0.007, respectively). The d-HDL and was found to be significantly higher in PCOS patients compared to the healthy controls (0.56 (0.24) vs. 0.50 (0.12), p<0.0001). There were also significant associations between the oxidative parameters and PCOS related findings (p<0.05). Conclusion: Besides the increased MPO/PON1 ratio which defined as d-HDL, the increased MPO and decreased PON1 activities also supported the increased oxidative status in PCOS patients. Our results may be considered to draw attention to oxidative stress and dyslipidemia in PCOS patients, even in the early periods of the women life.
- Publication
Jinekoloji-Obstetrik & Neonatoloji Tip Dergisi, 2023, Vol 20, Issue 3, p1804
- ISSN
1304-5512
- Publication type
Article
- DOI
10.38136/jgon.1313215