We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HIF-1α facilitates glioma proliferation and invasion by activating pyroptosis signaling axis.
- Authors
Wang, Xin-Wei; Fu, Hao; Zhang, Ya-Min
- Abstract
Background: HIF-1α is thought to be a novel regulator which contributes to carcinogenesis. However, the mechanism underlying the effect of HIF-1α in gliomas remains largely unknown. Methods: In the research, we demonstrate that HIF-lα mRNA and protein levels are elevated in glioma cells. The colony formation assays, transwell assays, and wound-healing assays showed that overexpression of HIF-1α promoted proliferation and invasion of glioma cells. Results: Overexpression of HIF-lα also increased the expression of inflammatory factors related to pyrolysis (TNF-α, IL-10, and IL-1β) and protein related to pyrolysis signal pathway (NLRP3, ASC, caspase-1, GSDMD, and GSDME). Conclusions: Therefore, we speculate that HIF-1α promotes the proliferation and invasion of glial cells by regulating pyrolysis pathway. These results might provide a novel strategy and target for treatment of glioma.
- Subjects
GLIOMAS; PYROPTOSIS; NEUROGLIA; NLRP3 protein; CASPASES
- Publication
Chinese Neurosurgical Journal, 2024, Vol 10, Issue 1, p1
- ISSN
2057-4967
- Publication type
Article
- DOI
10.1186/s41016-024-00366-3