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- Title
PREPARATION AND CHARACTERIZATION OF MICROSPHERES UTILIZING RATE-CONTROLLING MEMBRANES FOR THE MANAGEMENT OF DIABETES MELLITUS.
- Authors
Patidar, Nitu; Farooqui, Nadeem A.; Jamindar, Darshan; Mishra, Dinesh K.; Goyal, Rajat; Chopra, Hitesh; Gautam, Rupesh K.
- Abstract
The present research work aimed at the formulation of film-coated microspheres incorporating glibenclamide drug and their evaluation for the management of diabetes mellitus (DM). Microspheres were prepared by solvent evaporation methodology by the usage of ethyl cellulose as polymer, ethanol and dichloromethane as solvents and Tween 80® as a non-ionic surfactant. The film-coated membrane was prepared by pan coating method, incorporating ethyl cellulose, isopropyl alcohol, diethyl phthalate and sodium lauryl sulfate. This film membrane was coated on microspheres with the help of a spray gun. The efficiency of entrapment of the film coated microspheres of F5* batch, among different formulations, is highest and comes out to be in the range of 76.65±0.58. The percentage yield was observed to be 73.32±0.14. Morphological studies conducted by scanning electron microscope show spherical microspheres of uniform size. In vitro drug release study conducted of the coated microspheres of glibenclamide shows the highest amount of release of 97.44% in the F5*batch. The best-fit model was determined by the highest R2 value. Further, the developed formulation helps in reduction in dose dumping, with better patient compliance, and also masks the bitter taste of the drug.
- Subjects
SODIUM dodecyl sulfate; MICROSPHERES; DIABETES; DIETHYL phthalate; NONIONIC surfactants; ETHYLCELLULOSE; PHTHALATE esters
- Publication
Indian Drugs, 2024, Vol 61, Issue 2, p51
- ISSN
0019-462X
- Publication type
Article
- DOI
10.53879/id.61.02.14270