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- Title
乳腺癌患者改良根治术后生活质量调查及复发转移的影响因素分析.
- Authors
黄正春; 杨 枋; 孙智强; 霍明生; 朱 斌; 俞 欣
- Abstract
Objective: To investigate the quality of life of breast cancer patients after modified radical operation and analyze the influencing factors of recurrence and metastasis. Methods: 197 patients with breast cancer who underwent modified radical mastectomy in our hospital from June 2012 to June 2014 were selected. The quality of life of patients with breast cancer was evaluated by Quality of life scale for breast cancer patients (FACT-B) at 3 months, 6 months and 12 months after operation. The basic treatment of breast cancer patients was analyzed by self-designed questionnaire, and the influencing factors of recurrence and metastasis after modified radical mastectomy were analyzed. Results: In this study, 197 questionnaires were sent out and 195 were recovered, the recovery rate was 98.98% (195/197). 73 of 195 patients had relapse and metastasis. 73 patients with relapse and metastasis were enrolled in the relapse and metastasis group, and 122 patients without relapse and metastasis were enrolled in the relapse and metastasis group. The scores of social / family status, physiological status, functional status, emotional status, additional items of concern, and overall quality of life of 195 cases of breast cancer showed an increasing trend (P < 0.05). The independent risk factors of recurrence and metastasis after modified radical mastectomywere infiltrative nonspecific cancer, tumorsize ≥ 2 cm, clinicalstage III, hormone receptor ER and PRnegative (P< 0.05), while p53 protein positive expression, chemotherapy regimen, radiochemotherapy and endocrine therapy were independent protective factors of recurrence and metastasis after modified radical mastectomy (P < 0.05). Conclusion: The quality of life of patients with breast cancer after modified radical operation changes dynamically, the influencing factors of postoperative recurrence and metastasis are pathological type, clinical stage, tumor size, hormone receptor, chemotherapy plan, p53 protein, endocrine therapy, radiotherapy and chemotherapy.
- Subjects
P53 protein; HORMONE receptors; HORMONE therapy; BREAST cancer; CANCER patients; HORMONE receptor positive breast cancer; RADIOEMBOLIZATION
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 5, p984
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.05.041